Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids

LeBoeuf SE, Wu WL, Karakousi TR, Karadal B, Jackson SR, Davidson SM, Wong KK, Koralov SB, Sayin VI, Papagiannakopoulos T.

Cell Metab. 2020 Feb 4;31(2):339-350.e4. doi: 10.1016/j.cmet.2019.11.012. Epub 2019 Dec 5.

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Metabolic features of cancer cells in NRF2 addiction status

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In Vivo Epigenetic CRISPR Screen Identifies Asf1a as an Immunotherapeutic Target in Kras-Mutant Lung Adenocarcinoma