Rlf-Mycl Gene Fusion Drives Tumorigenesis and Metastasis in a Mouse Model of Small Cell Lung Cancer

Ciampricotti M, Karakousi T, Richards AL, Quintanal-Villalonga À, Karatza A, Caeser R, Costa EA, Allaj V, Manoj P, Spainhower KB, Kombak FE, Sanchez-Rivera FJ, Jaspers JE, Zavitsanou AM, Maddalo D, Ventura A, Rideout WM 3rd, Akama-Garren EH, Jacks T, Donoghue MTA, Sen T, Oliver TG, Poirier JT, Papagiannakopoulos T #, Rudin CM#.

# Co-corresponding author

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Activation of the NRF2 antioxidant program sensitizes tumors to G6PD inhibition

Ding H, Chen Z, Wu K, Huang SM, Wu WL, LeBoeuf SE, Pillai RG, Rabinowitz JD, Papagiannakopoulos T.

Sci Adv. 2021 Nov 19;7(47):eabk1023. doi: 10.1126/sciadv.abk1023. Epub 2021 Nov 17.

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Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment

Kerk SA, Papagiannakopoulos T, Shah YM, Lyssiotis CA.

Nat Rev Cancer. 2021 Aug;21(8):510-525. doi: 10.1038/s41568-021-00375-9. Epub 2021 Jul 9.

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Hunger brings down the tumor fort

Zavitsanou AM, Papagiannakopoulos T.

Trends Cell Biol. 2021 Aug;31(8):616-617. doi: 10.1016/j.tcb.2021.05.005. Epub 2021 May 22.

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The Center Cannot Hold: NRF2 Battles Ferroptosis in the 3rd Dimension

Wu WL, Papagiannakopoulos T.

Mol Cell. 2020 Dec 3;80(5):760-761. doi: 10.1016/j.molcel.2020.11.022.

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The Pleiotropic Role of the KEAP1/NRF2 Pathway in Cancer

Wu WL, Papagiannakopoulos T.

Annual Reviews of Cancer Biology.

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Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids

LeBoeuf SE, Wu WL, Karakousi TR, Karadal B, Jackson SR, Davidson SM, Wong KK, Koralov SB, Sayin VI, Papagiannakopoulos T.

Cell Metab. 2020 Feb 4;31(2):339-350.e4. doi: 10.1016/j.cmet.2019.11.012. Epub 2019 Dec 5.

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Nrf2 activation promotes lung cancer metastasis by inhibiting the degradation of Bach1

Lignitto L., LeBoeuf S., Homer H., Jiang S., Askenazi M., Karakousi T., Pass H., Bhutkar A., Tsirigos A., Ueberheide B., Sayin V., Papagiannakopoulos #T, and Pagano M#. Cell online, 2019.

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Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

Sayin VI*, LeBoeuf SE*, Singh SX, Davidson SM, Biancur D, Guzelhan BS, Alvarez SW, Wu WL, Karakousi TR, Zavitsanou AM, Ubriaco J, Muir A, Karagiannis D, Morris PJ, Thomas CJ, Possemato R, Vander Heiden MG, Papagiannakopoulos T.

Elife. 2017 Oct 2;6. pii: e28083. doi: 10.7554/eLife.28083.

*First Co-Author

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Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis

Romero R*, Sayin VI*, Davidson SM, Bauer MR, Singh SX, LeBoeuf SE, Karakousi TR, Ellis DC, Bhutkar A, Sánchez-Rivera FJ, Subbaraj L, Martinez B, Bronson RT, Prigge JR, Schmidt EE, Thomas CJ, Goparaju C, Davies A, Dolgalev I, Heguy A, Allaj V, Poirier JT, Moreira AL, Rudin CM, Pass HI, Vander Heiden MG, Jacks T #, Papagiannakopoulos T #.

Nat Med. 2017 Oct 2. doi: 10.1038/nm.4407.

# Co-corresponding author

*First Co-Author

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Pan-cancer transcriptomic analysis associates long non-coding RNAs with key driver mutational events

Ashouri, A.*; Sayin, V.I.*; Van den Eynden, J.; Papagiannakopoulos, T.#; Larsson E. #

Nature Communications. (2016).

# Co-corresponding author *First Co-Author

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Circadian Rhythm Disruption Promotes Lung Tumorigenesis

Papagiannakopoulos T, Bauer MR, Davidson SM, Heimann M, Subbaraj L, Bhutkar A, Bartlebaugh J, Vander Heiden MG, Jacks T.

Cell Metabolism. 2016. Aug 9;24(2):324-31. doi: 10.1016/j.cmet.2016.07.001. Epub 2016 Jul 28. PMID: 27476975

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Rapid modeling of cooperating genetic events in cancer through somatic genome editing

Sánchez-Rivera, F. J. *; Papagiannakopoulos, T.*; Romero, R.; Tammela, T.; Bauer, M. R.; Bhutkar, A.; Joshi, N.S.; Subbaraj, L.; Bronson, R. T.; Xue, X.; Jacks, T.

Nature. (2014), doi:10.1038/nature13906

*First Co-Author

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Genetic and clonal dissection of murine small cell lung cancer progression by genome sequencing

McFadden DG*, Papagiannakopoulos T.*, Taylor-Weiner A*, Stewart C*, Carter SL*, Cibulskis K, Bhutkar A , McKenna A, Dooley A, Vernon A, Sougnez C, Malstrom S, Heimann M, Park J, Chen F, Farago AF, Dayton T, Shefler E, Gabriel S, Getz G, Jacks T. (2013)

Cell 156, 1298-1311, doi:10.1016/j.cell.2014.02.031 (2014).

*First Co-Authors

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