DNA Methylation Profiling Identifies Subgroups of Lung Adenocarcinoma with Distinct Immune Cell Composition, DNA Methylation Age, and Clinical Outcome

Guidry K, Vasudevaraja V, Labbe K, Mohamed H, Serrano J, Guidry BW, DeLorenzo M, Zhang H, Deng J, Sahu S, Almonte C, Moreira AL, Tsirigos A, Papagiannakopoulos T, Pass H, Snuderl M, Wong KK.

Clin Cancer Res. 2022 Sep 1;28(17):3824-3835. doi: 10.1158/1078-0432.CCR-22-0391. PMID: 35802677

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NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer

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NRF2: KEAPing Tumors Protected