NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer

Weiss-Sadan T, Ge M, Hayashi M, Gohar M, Yao CH, de Groot A, Harry S, Carlin A, Fischer H, Shi L, Wei TY, Adelmann CH, Wolf K, Vornbäumen T, Dürr BR, Takahashi M, Richter M, Zhang J, Yang TY, Vijay V, Fisher DE, Hata AN, Haigis MC, Mostoslavsky R, Bardeesy N, Papagiannakopoulos T, Bar-Peled L.

Cell Metab. 2023 Mar 7;35(3):487-503.e7. doi: 10.1016/j.cmet.2023.01.012. Epub 2023 Feb 24. PMID: 36841242

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NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer

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DNA Methylation Profiling Identifies Subgroups of Lung Adenocarcinoma with Distinct Immune Cell Composition, DNA Methylation Age, and Clinical Outcome