Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer
Sayin VI*, LeBoeuf SE*, Singh SX, Davidson SM, Biancur D, Guzelhan BS, Alvarez SW, Wu WL, Karakousi TR, Zavitsanou AM, Ubriaco J, Muir A, Karagiannis D, Morris PJ, Thomas CJ, Possemato R, Vander Heiden MG, Papagiannakopoulos T.
Elife. 2017 Oct 2;6. pii: e28083. doi: 10.7554/eLife.28083.
*First Co-Author
Sayin VI*, LeBoeuf SE*, Singh SX, Davidson SM, Biancur D, Guzelhan BS, Alvarez SW, Wu WL, Karakousi TR, Zavitsanou AM, Ubriaco J, Muir A, Karagiannis D, Morris PJ, Thomas CJ, Possemato R, Vander Heiden MG, Papagiannakopoulos T.
Elife. 2017 Oct 2;6. pii: e28083. doi: 10.7554/eLife.28083.
*First Co-Author
Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis
Romero R*, Sayin VI*, Davidson SM, Bauer MR, Singh SX, LeBoeuf SE, Karakousi TR, Ellis DC, Bhutkar A, Sánchez-Rivera FJ, Subbaraj L, Martinez B, Bronson RT, Prigge JR, Schmidt EE, Thomas CJ, Goparaju C, Davies A, Dolgalev I, Heguy A, Allaj V, Poirier JT, Moreira AL, Rudin CM, Pass HI, Vander Heiden MG, Jacks T #, Papagiannakopoulos T #.
Nat Med. 2017 Oct 2. doi: 10.1038/nm.4407.
# Co-corresponding author
*First Co-Author
Romero R*, Sayin VI*, Davidson SM, Bauer MR, Singh SX, LeBoeuf SE, Karakousi TR, Ellis DC, Bhutkar A, Sánchez-Rivera FJ, Subbaraj L, Martinez B, Bronson RT, Prigge JR, Schmidt EE, Thomas CJ, Goparaju C, Davies A, Dolgalev I, Heguy A, Allaj V, Poirier JT, Moreira AL, Rudin CM, Pass HI, Vander Heiden MG, Jacks T #, Papagiannakopoulos T #.
Nat Med. 2017 Oct 2. doi: 10.1038/nm.4407.
# Co-corresponding author
*First Co-Author
Pan-cancer transcriptomic analysis associates long non-coding RNAs with key driver mutational events
Ashouri, A.*; Sayin, V.I.*; Van den Eynden, J.; Papagiannakopoulos, T.#; Larsson E. #
Nature Communications. (2016).
# Co-corresponding author *First Co-Author
Ashouri, A.*; Sayin, V.I.*; Van den Eynden, J.; Papagiannakopoulos, T.#; Larsson E. #
Nature Communications. (2016).
# Co-corresponding author *First Co-Author
Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers
Mayers JR, Torrence ME, Danai LV, Papagiannakopoulos T, Davidson SM, Bauer MR, Lau AN, Ji BW, Dixit PD, Hosios AM, Muir A, Chin CR, Freinkman E, Jacks T, Wolpin BM, Vitkup D, Vander Heiden MG.
Science. 2016 Sep 9;353(6304):1161-5. doi: 10.1126/science.aaf5171.
Mayers JR, Torrence ME, Danai LV, Papagiannakopoulos T, Davidson SM, Bauer MR, Lau AN, Ji BW, Dixit PD, Hosios AM, Muir A, Chin CR, Freinkman E, Jacks T, Wolpin BM, Vitkup D, Vander Heiden MG.
Science. 2016 Sep 9;353(6304):1161-5. doi: 10.1126/science.aaf5171.
Circadian Rhythm Disruption Promotes Lung Tumorigenesis
Papagiannakopoulos T, Bauer MR, Davidson SM, Heimann M, Subbaraj L, Bhutkar A, Bartlebaugh J, Vander Heiden MG, Jacks T.
Cell Metabolism. 2016. Aug 9;24(2):324-31. doi: 10.1016/j.cmet.2016.07.001. Epub 2016 Jul 28. PMID: 27476975
Papagiannakopoulos T, Bauer MR, Davidson SM, Heimann M, Subbaraj L, Bhutkar A, Bartlebaugh J, Vander Heiden MG, Jacks T.
Cell Metabolism. 2016. Aug 9;24(2):324-31. doi: 10.1016/j.cmet.2016.07.001. Epub 2016 Jul 28. PMID: 27476975
Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis
Masri S, Papagiannakopoulos T, Kinouchi K, Liu Y, Cervantes M, Baldi P, Jacks T, Sassone-Corsi P.
Cell. 2016; 165(4):896-909. PubMed [journal] PMID: 27153497
Masri S, Papagiannakopoulos T, Kinouchi K, Liu Y, Cervantes M, Baldi P, Jacks T, Sassone-Corsi P.
Cell. 2016; 165(4):896-909. PubMed [journal] PMID: 27153497
Application of CRISPR-mediated genome engineering in cancer research
Sayin VI, Papagiannakopoulos T.
Cancer Lett. 2016 Mar 18. pii: S0304-3835(16)30179-3. doi: 10.1016/j.canlet.2016.03.029. [Epub ahead of print] PMID: 27000990
Sayin VI, Papagiannakopoulos T.
Cancer Lett. 2016 Mar 18. pii: S0304-3835(16)30179-3. doi: 10.1016/j.canlet.2016.03.029. [Epub ahead of print] PMID: 27000990
A Modular Assembly Platform for Rapid Generation of DNA Constructs
Akama-Garren EH, Joshi NS, Tammela T, Chang GP, Wagner BL, Lee DY, Rideout Iii WM, Papagiannakopoulos T, Xue W, Jacks T.
Sci Rep. 2016 Feb 18;6:16836. doi: 10.1038/srep16836.
Akama-Garren EH, Joshi NS, Tammela T, Chang GP, Wagner BL, Lee DY, Rideout Iii WM, Papagiannakopoulos T, Xue W, Jacks T.
Sci Rep. 2016 Feb 18;6:16836. doi: 10.1038/srep16836.
Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer
Davidson SM, Papagiannakopoulos T, Olenchock BA, Heyman JE, Keibler MA, Luengo A, Bauer MR, Jha AK, O'Brien JP, Pierce KA, Gui DY, Sullivan LB, Wasylenko TM, Subbaraj L, Chin CR, Stephanopolous G, Mott BT, Jacks T, Clish CB, Vander Heiden MG.
Cell Metab. 2016 Feb 3. pii: S1550-4131(16)00041-3. doi: 10.1016/j.cmet.2016.01.007. [Epub ahead of print]
Davidson SM, Papagiannakopoulos T, Olenchock BA, Heyman JE, Keibler MA, Luengo A, Bauer MR, Jha AK, O'Brien JP, Pierce KA, Gui DY, Sullivan LB, Wasylenko TM, Subbaraj L, Chin CR, Stephanopolous G, Mott BT, Jacks T, Clish CB, Vander Heiden MG.
Cell Metab. 2016 Feb 3. pii: S1550-4131(16)00041-3. doi: 10.1016/j.cmet.2016.01.007. [Epub ahead of print]
Rapid modeling of cooperating genetic events in cancer through somatic genome editing
Sánchez-Rivera, F. J. *; Papagiannakopoulos, T.*; Romero, R.; Tammela, T.; Bauer, M. R.; Bhutkar, A.; Joshi, N.S.; Subbaraj, L.; Bronson, R. T.; Xue, X.; Jacks, T.
Nature. (2014), doi:10.1038/nature13906
*First Co-Author
Sánchez-Rivera, F. J. *; Papagiannakopoulos, T.*; Romero, R.; Tammela, T.; Bauer, M. R.; Bhutkar, A.; Joshi, N.S.; Subbaraj, L.; Bronson, R. T.; Xue, X.; Jacks, T.
Nature. (2014), doi:10.1038/nature13906
*First Co-Author
Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development
Mayers JR, Wu C, Clish CB, Kraft P, Torrence ME, Fiske BP, Yuan C, Bao Y, Townsend MK, Tworoger SS, Davidson SM, Papagiannakopoulos T, Yang A, Dayton TL, Ogino S, Stampfer MJ, Giovannucci EL, Qian ZR, Rubinson DA, Ma J, Sesso HD, Gaziano JM, Cochrane BB, Liu S, Wactawski-Wende J, Manson JE, Pollak MN, Kimmelman AC, Souza A, Pierce K, Wang TJ, Gerszten RE, Fuchs CS, Vander Heiden MG, Wolpin BM.
Nat Med. 2014 Oct;20(10):1193-8. doi: 10.1038/nm.3686. Epub 2014 Sep 28.
Mayers JR, Wu C, Clish CB, Kraft P, Torrence ME, Fiske BP, Yuan C, Bao Y, Townsend MK, Tworoger SS, Davidson SM, Papagiannakopoulos T, Yang A, Dayton TL, Ogino S, Stampfer MJ, Giovannucci EL, Qian ZR, Rubinson DA, Ma J, Sesso HD, Gaziano JM, Cochrane BB, Liu S, Wactawski-Wende J, Manson JE, Pollak MN, Kimmelman AC, Souza A, Pierce K, Wang TJ, Gerszten RE, Fuchs CS, Vander Heiden MG, Wolpin BM.
Nat Med. 2014 Oct;20(10):1193-8. doi: 10.1038/nm.3686. Epub 2014 Sep 28.
CRISPR-mediated direct mutation of cancer genes in the mouse liver
Xue, W., Chen, S., Yin, H., Tammela, T., Papagiannakopoulos, T., Joshi, N. S., Cai, W., Yang, G., Bronson, R., Crowley, D. G., Zhang, F., Anderson, D. G., Sharp, P. A. & Jacks, T.
Nature, doi:10.1038/nature13589 (2014).
Xue, W., Chen, S., Yin, H., Tammela, T., Papagiannakopoulos, T., Joshi, N. S., Cai, W., Yang, G., Bronson, R., Crowley, D. G., Zhang, F., Anderson, D. G., Sharp, P. A. & Jacks, T.
Nature, doi:10.1038/nature13589 (2014)
Genetic and clonal dissection of murine small cell lung cancer progression by genome sequencing
McFadden DG*, Papagiannakopoulos T.*, Taylor-Weiner A*, Stewart C*, Carter SL*, Cibulskis K, Bhutkar A , McKenna A, Dooley A, Vernon A, Sougnez C, Malstrom S, Heimann M, Park J, Chen F, Farago AF, Dayton T, Shefler E, Gabriel S, Getz G, Jacks T. (2013)
Cell 156, 1298-1311, doi:10.1016/j.cell.2014.02.031 (2014).
*First Co-Authors
McFadden DG*, Papagiannakopoulos T.*, Taylor-Weiner A*, Stewart C*, Carter SL*, Cibulskis K, Bhutkar A , McKenna A, Dooley A, Vernon A, Sougnez C, Malstrom S, Heimann M, Park J, Chen F, Farago AF, Dayton T, Shefler E, Gabriel S, Getz G, Jacks T. (2013)
Cell 156, 1298-1311, doi:10.1016/j.cell.2014.02.031 (2014).
*First Co-Authors