Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis

Romero R*, Sayin VI*, Davidson SM, Bauer MR, Singh SX, LeBoeuf SE, Karakousi TR, Ellis DC, Bhutkar A, Sánchez-Rivera FJ, Subbaraj L, Martinez B, Bronson RT, Prigge JR, Schmidt EE, Thomas CJ, Goparaju C, Davies A, Dolgalev I, Heguy A, Allaj V, Poirier JT, Moreira AL, Rudin CM, Pass HI, Vander Heiden MG, Jacks T #, Papagiannakopoulos T #.

Nat Med. 2017 Oct 2. doi: 10.1038/nm.4407.

# Co-corresponding author

*First Co-Author

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Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

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Pan-cancer transcriptomic analysis associates long non-coding RNAs with key driver mutational events