Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

Sayin VI*, LeBoeuf SE*, Singh SX, Davidson SM, Biancur D, Guzelhan BS, Alvarez SW, Wu WL, Karakousi TR, Zavitsanou AM, Ubriaco J, Muir A, Karagiannis D, Morris PJ, Thomas CJ, Possemato R, Vander Heiden MG, Papagiannakopoulos T.

Elife. 2017 Oct 2;6. pii: e28083. doi: 10.7554/eLife.28083.

*First Co-Author

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NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

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Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis