In vivo metabolomics identifies CD38 as an emergent vulnerability in LKB1 -mutant lung cancer

Deng J, Peng DH, Fenyo D, Yuan H, Lopez A, Levin DS, Meynardie M, Quinteros M, Ranieri M, Sahu S, Lau SCM, Shum E, Velcheti V, Punekar SR, Rekhtman N, Dowling CM, Weerasekara V, Xue Y, Ji H, Siu Y, Jones D, Hata AN, Shimamura T, Poirier JT, Rudin CM, Hattori T, Koide S, Papagiannakopoulos T, Neel BG, Bardeesy N, Wong KK.

bioRxiv. 2023 Apr 20:2023.04.18.537350. doi: 10.1101/2023.04.18.537350. Preprint. PMID: 37131623

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Metabolic Reprogramming by Histone Deacetylase Inhibition Selectively Targets NRF2-activated tumors

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NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer