NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer

Weiss-Sadan T, Ge M, Hayashi M, Gohar M, Yao CH, de Groot A, Harry S, Carlin A, Fischer H, Shi L, Wei TY, Adelmann CH, Wolf K, Vornbäumen T, Dürr BR, Takahashi M, Richter M, Zhang J, Yang TY, Vijay V, Fisher DE, Hata AN, Haigis MC, Mostoslavsky R, Bardeesy N, Papagiannakopoulos T, Bar-Peled L.

Cell Metab. 2023 Apr 4;35(4):722. doi: 10.1016/j.cmet.2023.03.011. PMID: 37019082

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NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer