Metabolic Reprogramming by Histone Deacetylase Inhibition Selectively Targets NRF2-activated tumors

Karagiannis D, Wu W, Li A, Hayashi M, Chen X, Yip M, Mangipudy V, Xu X, Sánchez-Rivera FJ, Soto-Feliciano YM, Ye J, Papagiannakopoulos T, Lu C.

bioRxiv. 2023 Apr 28:2023.04.24.538118. doi: 10.1101/2023.04.24.538118. Preprint. PMID: 37162970

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SOX9 drives KRAS-induced lung adenocarcinoma progression and suppresses anti-tumor immunity

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In vivo metabolomics identifies CD38 as an emergent vulnerability in LKB1 -mutant lung cancer